Resveratrol: Promotes stem cell proliferation, differentiation and a host of other benefits

Resveratrol has been gaining increasing popularity as of late. Most people, when they learn about its positive effects and that it can be found in red wine, will chuckle and use it as an excuse to have a glass. Of course, alcohol, sugar, and calories can offset the benefits, so the ideal intake is to supplement with a purified extract if a person is going to take resveratrol.



There has been much research supporting resveratrol's beneficial effects ranging from anti-oxidant, anti-inflammatory, anti-cancer, and promoting improved cardiovascular risk and blood flow among other things. More recently, research has shown resveratrol can promote stem cell proliferation and function. A study done in 2018 was done comparing mesenchymal stem cells (MSCs) derived from inflammatory environments vs those derived in non-inflammatory environments found that resveratrol protected and improved the MSCs function in pro inflammatory environments. It also showed that it helped the MSCs in non-inflammatory environments. An excerpt from the study summarizes the findings quite nicely:


Resveratrol (RSV) is a natural phytoalexin that exhibits reliable and widespread rejuvenative effects in various animal models, tissues and organs, and most notably, in stem cells. For MSCs, RSV has effects on cell viability, osteogenic differentiation, and paracrine secretion in vitro. When administered in vivo, in combination with MSCs, RSV enhances MSC-mediated liver and cardiac regeneration by improving the homing and survival of MSCs. On the other hand, RSV has been reported to have anti-inflammatory properties and inhibitory effects on the nuclear factor kappaB (NFkB) pathway, a key inflammatory signaling pathway. Given the above findings, we hypothesize that RSV application may serve as a feasible method to promote the tissue regeneration of MSCs derived from inflammatory microenvironments.


The authors of the study then performed a comparison of a specific type of MSC, called a periodontal ligament stem cell, and they isolated the cells from those with the inflammatory condition called periodontitis and those that were healthy. They compared the two populations of cells and studied each groups ability to differentiation, rejuvenate and overall functional capacity. The results showed that the cells derived from an inflammatory environment were impaired and inferior in functioning to the cells from the normal environment. Then, the exposed both groups to resveratrol and found the it was protective and restored and promoted the stem cells derived from the inflammatory environment to behave more like the stem cells derived from the healthy environment. Futhermore, it was shown that resveratrol was beneficial to the stem cells from the normal environment as well.


Research has shown that resveratrol has a number of promising benefits in general. This study lends additional support to those who have had stem cell therapies and may have inflammation. Resveratrol may be additionally beneficial for this group of patients, and likely anyone else in general.


Resveratrol is just one of the carefully chosen components of StemLife, a comprehensive supplement designed to promote and support stem cells and cellular health in general.



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